Ultrastructure of Desmosomes in Mammalian Intercalated Disc; Appearances after Lanthanum Treatment
نویسندگان
چکیده
At points of desmosomal contact between cells a suggestion of intercellular cross-connections has been reported (1) and an electron-opaque line is often seen midway between the apposed membranes (2, 3), but the nature of this and other extracellular components of the desmosome is still uncertain . The use of lanthanum as an extracellular marker (4) has provided new information about the structure of the desmosome .
منابع مشابه
The Ultrastructure of Cardiac Desmosomes in the Toad and Their Relationship to the Intercalated Disc
The fine structure of desmosomes and intercalated discs in the toad heart is discussed. A definite relationship between the dense components of these structures and the dense region of the Z band is demonstrated. The dense region of the Z band characteristically widens at its approach to the plasma membrane, and often terminates beneath it in a distinct discoidal plaque. Cardiac desmosomes appe...
متن کاملThe organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions.
Adherens junctions and desmosomes are responsible for mechanically coupling myocytes in the heart and are found closely apposed to gap junction plaques at the intercalated discs of cardiomyocytes. It is not known whether loss of cardiac gap junctions, such as described in cardiac disease states, may influence the expression patterns of other intercalated disc-associated proteins. We investigate...
متن کاملمقایسه فراساختار تکوین کاردیومیوسیتهای مشتق از بنیاختههای جنینی موش با کاردیومیوسیتهای طبیعی
Introduction: Stem cell biology has been the subject of much recent discussion. Embryonic stem (ES) cells, derived from the inner cell mass of the blastocyst stage of early mammalian embryos are expected to become a powerful tool in future regenerative medicine and developmental biology due to their capacity of self-renewal and pluripotency. In the present study, the ultrastructural development...
متن کاملA New Perspective on Intercalated Disc Organization: Implications for Heart Disease
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin. The different junction complexes are organized at the termini of the cardiomyocyte called the intercalated disc. Disruption of adhesive integrity via mutations in genes enco...
متن کاملReleasing YAP from an α-catenin trap increases cardiomyocyte proliferation.
A dult mammalian cardiomyocytes possess little endoge-nous proliferative capacity. This innate limitation underlies our inability to reverse heart failure and improve patient outcome after myocardial injury. The mechanisms that restrict adult mammalian cardiomyocyte proliferation have been the intensely scrutinized, and molecular insights are slowly emerging. 1 In this issue of Circulation Rese...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 42 شماره
صفحات -
تاریخ انتشار 1969